Psychology and psychiatry of epigenetics

In a groundbreaking 2003 report, Caspi and colleagues demonstrated that in a robust cohort of over one-thousand subjects assessed multiple times from preschool to adulthood, subjects who carried one or two copies of the short allele of the serotonin transporter promoter polymorphism exhibited higher rates of adult depression and suicidality when exposed to childhood maltreatment when compared to long allele homozygotes with equal ELS exposure.

Parental nutrition, in utero exposure to stress, male-induced maternal effects such as attraction of differential mate quality, and maternal as well as paternal age, and offspring gender could all possibly influence whether a germline epimutation is ultimately expressed in offspring and the degree to which intergenerational inheritance remains stable throughout posterity.

Addiction is a disorder of the brain's reward system which arises through transcriptional and neuroepigenetic mechanisms and occurs over time from chronically high levels of exposure to an addictive stimulus (e.g., morphine, cocaine, sexual intercourse, gambling, etc.). Transgenerational epigenetic inheritance of addictive phenotypes has been noted to occur in preclinical studies.

Transgenerational epigenetic inheritance of anxiety-related phenotypes has been reported in a preclinical study using mice. In this investigation, transmission of paternal stress-induced traits across generations involved small non-coding RNA signals transmitted via the male germline.

Epigenetic inheritance of depression-related phenotypes has also been reported in a preclinical study. Inheritance of paternal stress-induced traits across generations involved small non-coding RNA signals transmitted via the paternal germline.

Studies on mice have shown that certain conditional fears can be inherited from either parent. In one example, mice were conditioned to fear a strong scent, acetophenone, by accompanying the smell with an electric shock. Consequently, the mice learned to fear the scent of acetophenone alone. It was discovered that this fear could be passed down to the mice offspring. Despite the offspring never experiencing the electric shock themselves the mice still displayed a fear of the acetophenone scent, because they inherited the fear epigenetically by site-specific DNA methylation. These epigenetic changes lasted up to two generations without reintroducing the shock.

DEFINITIONS OF EPIGENETICS

MOLECULAR BASIS OF EPIGENETICS

MECHANISMS OF EPIGENETICS

EPIGENETICS IN BACTERIA

MEDICINE AND EPIGENETICS

PSYHOLOGY AND PSYCHIATRY OF EPIGENETICS

SCHEDULE OF EVENTS

PROGRAM

EXHIBITORS
SPONSORS

ABSTRACT
SUBMISSIONS

ABOUT OKC

CONTACT

HOME